The study of genetic and environmental factors influencing energy balance using laboratory animals has been advanced by the introduction of indirect calorimetry systems ( Even and Nadkarni, 2012). Mice are an instructive tool for the study of human metabolism as they can mirror human physiology in their responses to age-related and diet-induced obesity, and their physiological compensations to resist weight loss ( Speakman et al., 2007). Further studies are needed to identify these factors. also found that other unknown factors also affect mouse metabolism in different laboratories. This can help scientists compare results and repeat experiments, which could speed up research into mouse metabolism. These results suggest that it is important for scientists to report factors like room temperatures, the body make-up of the mice, or the animals’ activity levels in metabolism studies. These two factors affected the metabolism of both typical mice and mice with mutations that affect their energy balance. examined data from more than 30,000 mice at laboratories around the world to show that room temperatures and the amount of muscle and fat in a mouse’s body have the biggest influence on energy balance. Identifying the effects of such differences is essential, but it requires looking at data from hundreds of mice.Ĭorrigan et al. For example, the temperatures of the mouse cages or how active the mice are might differ depending on the laboratory. These discrepancies could be due to small differences between how mice are kept in different laboratories. This makes it hard to determine what is ‘normal’ for mouse metabolism. To better understand metabolism, scientists often study mice in laboratories, but mice from different laboratories appear to convert food to energy at different rates. Genetic and environmental factors can affect energy metabolism and energy balance contributing to conditions like obesity. The body converts food to energy through a process called energy metabolism. Maintaining a healthy weight requires the body to balance energy intake and expenditure. These recommendations will move us closer to the goal of a centralized physiological repository to foster transparency, rigor and reproducibility in metabolic physiology experimentation. Based on these findings, we provide suggestions for how best to design and conduct energy balance experiments in rodents. We also analyze variation in 2329 knockout strains and establish a reference for the magnitude of metabolic changes.

Analysis of nearly 10,000 wild-type mice from two large-scale experiments revealed that the largest variation in energy expenditure is due to body composition, ambient temperature, and institutional site of experimentation. Energy metabolism is measured by powerful and sensitive indirect calorimetry devices.

To understand the genetic and environmental factors that contribute to the regulation of body weight, an important first step is to establish the normal range of metabolic values and primary sources contributing to variability. I also built my own social media network on my website MuscularStrength.Maintaining a healthy body weight requires an exquisite balance between energy intake and energy expenditure. Now, I am the leader of a YouTube community with MILLIONS of subscribers worldwide (/ScottHermanFitness) and produce fitness content on a weekly basis! I became a cast member on “The Real World: Brooklyn Season 21”! in 2009 and with the rapid rise in popularity of social media networks all over the world I was able to utilize this opportunity as a platform to get my message of fitness out to the masses.

Just a few short years later I saw my dreams coming true. During my gym years, I realized that many people could not afford personal training and I decided to help underprivileged members by creating short exercise demonstration videos and posting them on YouTube and on my website. Then after obtaining my Bachelor’s Degree in Business Administration, I launched (Now ) in 2007 with the dream of revolutionizing the fitness industry. I began my journey as a maintenance employee cleaning and fixing gym equipment and had every job from personal training to sales & marketing until I became a General Manager. Growing up in a gym not only allowed me to attain a great physique but also taught me everything I needed to know about fitness. I started working in a gym at the age of 14 and right away realized that I had found my true passion. Exercise and fitness became a part of my life at a very young age.

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